The crash occurred about 9:30 a.m. Saturday on Route 1 at Carnegie Center Boulevard in West Windsor, initial reports said.
The motorist reportedly was trapped and had to be airlifted by medical helicopter to an area hospital, reports said.
About 1:30 p.m., there was a separate crash reported in Trenton at North Hermitage Avenue and West State Street. Two crash victims were taken to a regional hospital, according to initial reports.
Additional details were not immediately available.
Click here to follow Daily Voice Hamilton Township and receive free news updates.